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Hgb S is a result of minor changes in the molecular structure causing profound changes in
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- Blood proteins = Are Buffers for pH!- Temperature- Influences intracellular water content (oncotic vs hydrostatic pressures)
- 1) Immune reaction (hives, fever, resp. distress, hypotension)2) Hemolysis- release when Hb is metabolized (and eventually jaundice)3) Kidney shutdown- Toxic substances released from hemolyzing blood- Renal vasoconstriction- And Hb leak thru glomeruli, blocking kidney tubules