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Thyroxin is secreted by the thyroid gland, which is located in the neck. Thyroxin contains three or four iodine atoms. Most cells of the body are targets for thyroxin. It regulates metabolism. Thyroxin binding to target cells increases metabolic rate. A high metabolic rate will generate heat. Thyroxin plays a role in regulating body temperature: Low body temperature increases thyroxin release. This increases metabolic activity, which raises body temperature. High body temperature decreases thyroxin release. This reduces metabolic activity, which lowers body temperature. Iodine deficiency in the diet can lead to low levels of thyroxin (leading to an enlarged thyroid gland or goitre). Iodine is commonly added to table salt to avoid this problem.

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