- Hyperadrenocorticism, or high Cortisol levels, is the main cause of Cushing's Disease. The most common cause of high cortisol levels is a tumor in the pituitary (ACTH-dependent). The other, less common, cause of high cortisol is due to a ____________ in the _____________ __________. This does NOT rely on ACTH.
- PPID, or Cushing's Dz in horses, results in high cortisol levels due to a lack of ____________.
- Addison's Disease in dogs is most likely due to _________ to the adrenal gland.
- During parturition, there is an increase in __________ for _________ ______________ of the fetus (think of surfactant).
- What stimulates Aldosterone production and secretion from the Zona Glomerulosa in the Adrenal Gland?
- True or False: Glucocorticoids just treat the inflammatory appearance of a condition, not the underlying cause.
- True or False: Cortisol can be active and inactive. Cortisol is only active in areas that is in need of it.
- The Hypothalamus activates the pituitary gland to release ______ to stimulate the Adrenal Gland to secrete Cortisol.
- True or False: Prolonged use of Glucocorticoids can cause a decrease in hair growth and skin thickness.
- ____________ is produced by the Kidney to form the Angiotensin I enzyme is converted to ________________ ____ by ACE to produce Aldosterone.
- ___________ are __________ are 2 reasons Aldosterone may be secreted due to a decrease in extracellular fluid and Na+.
- Glucocorticoids are a class of drugs that have an ______________ affect.
- Cortisol is a ______________ that can affect many target organs.
- If you "give" Aldosterone to an animal, there will be a drastic _____________ in Na+ excretion in the urine, an __________ in extracellular fluid volume... therefore your blood pressure (vasoconstriction) will ______________.
- Renin secretion by the kidneys is increased by ___________________.
- Cortisol secretion is stimulated by ___________.
- If you have an increase in blood pressure and Na+, you will decrease the secretion of _________________.
- ACTH binds to its receptor in the Adrenal Gland to induce the ________ pathway to secrete Cortisol into the blood.
- Renin is produced by the ____________.
- People with Hypertension (high blood pressure) take an _____ inhibitor drug to control their blood pressure. This class of drugs blocks the ______ enzyme, therefore preventing Angiotensin II (which causes an increase in BP).