- What two groups of Sedative-Hypnotic drugs, exert inhibitory effects on polysynaptic reflexes and at high doses may also depress transmission at the skeletal neuromuscular junction?
- Binding of what to BZ receptors facilitate /potentiate the inhibitory actions of GABA?
- What is a selective anxiolytic, with minimal depressant effects on the CNS?
- What stage of sleep is characterized by (70%-75% of sleep) N1, N2, N3 (deep or slow wave sleep)?
- What is usually accompanied by some impairment of psychomotor functions and cognitive functions?
- What type of GABA receptor is characterized by G protein coupled receptors and Activation causes K+ efllux
- The steepness of the dose-response curve varies among drug groups. What can be determined by the flatness of the curve?
- What does the CNS effects of most sedative-hypnotics depend on?
- What promotes sleep onset and increase the duration of the sleep state?
- What class of Sedative-Hypnotic Drugs inhibit complex I of electron transport chain?
- What class of Sedative-Hypnotic Drugs may block the excitatory transmitter glutamic acid, and, at high concentration, sodium channels?
- What sedative-hypnotic drugs exert calming effects with concomitant reduction of anxiety at relatively low doses?
- What class does the anxiolytic drug belong to that interacts with the 5-hydroxytryptophan (5-HT1A) brain serotonin receptors as a partial agonist, but the precise mechanism of its anxiolytic effect is unknown?
- Why is the dependence liability of zolpidem, zaleplon, and eszopiclone may be less than that of the benzodiazepines?
- What type of BZ receptors mediate sedation?
- What does not bind to BZ or GABA binding sites, but have their own site on the chloride ion channel?
- What increase the frequency of GABA-mediated chloride ion channel opening.
- Midazolam Oxazepam and Triazolam are benzodiazepines that have pharmacokinetics described as what?
- What reverses the CNS effects of benzodiazepines and is classified as a competitive antagonist at BZ receptors.
- What type of GABA receptor is characterized by Ionotropic receptors and Activation causes Cl- influx