- What is the most common type of phase II metabolism reaction?
- How does polarity affect volume of distribution?How does lipophilicity affect volume of distribution?
- Morphine and hydrocodone are parent drugs but also ? of codeine.
- The ? enzyme is one of the most involved CYPs.
- What type of CYP has the highest percentage of drugs metabolized by it?
- ? and ? are not commonly main elimination routes?
- When was CYP450 catalysis discovered?
- The parent compound can be a ? of another parent drug.
- What type of CYP has the highest relative hepatic content?
- Some drugs do not reach systemic ciruclation and get eliminated...
- What types of compounds are excreted through the lungs?
- Is the Vd higher for hydrophilic or lipophilic drugs?
- What does glomerular filtration depend on?- Rate?- What type of drugs are often eliminated through the bladder (in urine) in this step?
- Drugs are mostly metabolized by what enzyme systemes?
- What are common examples of hydrolysis reactions in drug metabolism?
- In some cases, ? can happen at both sites in phase II metabolism?
- What is important about heme for oxidation and reduction reactions?
- What type of phase I enzymes need a cofactor?
- What happens when lipophilic drugs are reabsorbed into the renal vein?
- What type of chemical reaction do CYP enzymes carry out in phase I metabolism?