- Panitumumab is a fully human monoclonal antibody that is directed against which receptor?
- Antimetabolites are structurally similar to endogenous compounds that are antagonists of which molecule?
- Asparaginase depletes serum levels of which molecule?
- Ziv-aflibercept works similarly to bevacizumab in that it targets which molecule?
- Antimetabolites act in which phase of the cell cycle?
- True/False: Direct acid neutralizers are used to neutralize 100% of acidity and have bactericidal activity of H. pylori.
- Cetuximab is a chimeric monoclonal antibody that is directed to the extracellular domain of which receptor?
- What type of drug is indicated by the suffix -ximab?
- Are natural product anticancer drugs CCS or CCNS?
- Bleomycin is composed of a mixture of which molecules?
- TKIs inhibit TK activity of which specific gene?
- Podophyllotoxins act during which phase of the cell cycle?
- What type of drug is indicated by the suffix -tinib?
- H. pylori or NSAID induced PUD?- Inhibition of COX --> Decreased PGE2 --> Increased acid secretion- Increased ICAM --> Mucosal damage via neutrophils- Trapped as an ion in epithelial cell --> Cellular injury
- What type of drug is indicated by the suffix -zumab?
- Ziv-aflibercept is used in treatment of which cancer?
- What is the adverse effect of sodium bicarbonate and calcium carbonate?
- Gefitinib and erlotinib are small molecule inhibitors of what?
- Cytarabine is activated by kinases into which molecule that inhibits DNA polymerases?
- Fluorouracil MOA:- Incorporation of _____ into DNA --> Inhibits _____ synthesis and function- Incorporation of _____ into RNA --> Inhibits _____ processing and function