- p53 is a protein with a ___________ half life present, in the normal situation, in very _________ concentrations in cells.
- grading of cancer - degree of _______________
- ____________ corrects mismatched bases
- __________ are central to adhesion, establish cell ______ and cell-cell ______________
- staging of cancer - invasion and metastasis - guides ____________
- p53 is a protector against ___________ oncogenes
- MMR corrects ___________/___________ loops that most commonly occur where short sequences are repeated
- what type of mutations occur in Lynch syndrome or Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
- squamous cell carcinomas the gene for the EGF-R can be amplified to many 100's of copies the cell is much more sensitive to ____________
- in _________ of mismatch repair, mutation rate increases 100-1000x
- TSGs are said to be "____________" in mechanism to wild type
- in carcinomas cadherins, b catenin, APC are ________ or ___________
- DNA strand break repair - what genes are involved in d/s break repair?
- aneuploidy often involves ____________________ (deletion)
- as angiogenesis of the tumour increases, what happens to it's size?
- chromosomal rearrangements in solid tumours, particularly carcinomas, are extensive, but __________ characteristic of a specific cancer type
- Transition from a growth regulated cell to a malignant cancer cell requires
- When DNA is damaged, p53 is stabilised and its concentration _____
- what controls the G1/S checkpoint?
- Final cancer diagnosis almost always involves tissue diagnosis by