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1/2/ Fixation primaire définitive avec ZP33/ Dépend Ca2+ : relarguage enzyme de acrosome + expo° récepteurs mbr4/ MAI avec ZP25/ Mvt hyperactif + spz dans espace perivitellin 6/ Fusion tangentielle à zone microvillaire (grâce à Izumo 1 (spz) et CD9 (ovocyte)) 7/PLCzeta --> libération IP3 --> liberation Ca2+ --> granules corticaux--> blocage polyspérmie + Syngamie + reprise méiose ovocyte
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