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*10.36 For rare genetic disorders that have only one mutant allele, genetic tests can be tailored to detect the mutant and normal alleles specifically. However, for more prevalent genetic disorders, such as anemia caused by mutations in - and -globin, Duchenne muscular dystrophycaused by mutations in the dystrophin gene, and cystic fibrosis caused by mutations in CFTR, there are many differentalleles at one gene that can lead to different disease phenotypes. These diseases present a challenge to genetic testing because, for these diseases, a genetic test that identifies only a single type of DNA change is inadequate. How can this challenge be overcome?
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