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A 54-year-old male patient who weighs 78kg is being prescribed clarithromycin for an infection to be given as 250mg tablets. The usual oral dose for this indication is 500 mg every twelve hours for seven days. This dose is reduced with poor renal function as detailed below If CrCl is... • >30 mL/min: Dose as in normal renal function • 30 mL/min: Half the normal dose The patient has a serum creatinine of 276 micromol/L CrCl (mL/min) = (N x (140-age) x weight (kg)) / Serum creatinine N= 1.23 in men and 1.04 in women How many clarithromycin tablets will this patient require for the full course based on their renal function?
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