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A 75 years old lady is taking warfarin tablets (a drug with a narrow therapeutic index) because of a previous pulmonary embolism. Due to having a chest infection with MRSA she has been started on the antibiotic rifampicin, an inducer of cytochrome P450 enzymes. Which of the following is an appropriate action?☐ A. Change her rifampicin to flucloxacillin☐ B. Increase her dose of Warfarin immediately☐ C. Monitor her warfarin level closely by checking INR in blood and adjust dose if necessary☐ D. Stop both her rifampicin and warfarin as they are a dangerous combination ☐ E. Stop her Warfarin while she is taking rifampicin
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