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agissent sur le cycle cellulaire des cellules cancéreuses ET saines et qui vont bloquer leur prolifération.• En altérant l'ADN (antimétabolites incorporés dans l'ADN qui bloquent la réplication)• En altérant le fuseau mitotique et donc la mitose ( inhibiteurs enzymatiques : bloquent la synthèse de précurseurs nécessaires à la réplication)pas ciblée sur les cellules cancéreuses, elle n'est pas spécifique (attaque des tissus sains explique les nombreux effets secondaires comme des troubles digestifs ou une perte de cheveux)
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