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AIDS 的NRTI藥物NRTI: 核酸類反轉錄酶抑制(阻斷3,5-磷酸雙酯鍵)、不具3-OH、需宿主kinase三磷酸化副作用: 強烈肝毒(除了Lamivudine、Abcavir)、乳酸中毒、脂肪變性肝腫唯一孕婦用: Zidovudine1.)Zidovudine (AZT): 胸腺knase磷酸化、孕婦/兒童可用、3,-azido(3個N)-3-deoxythymidine(2個N)→5個N副作用: 骨髓抑制/貧血不並用: Stavudine、Ribavirin2.)Didanosine (ddI): 轉成ddATP(干擾DNA延長)、耐酸(PO)、需+Na+、衍生物(inosine)副作用: 胰臟、周邊神經炎不並用: PKU、限鈉、尿酸(痛風)3.)Zalcitabine (ddC): 需活化/阻止DNA延長、衍生物(Cytosine C)副作用: 周邊神經炎、胰臟炎4.)Stavudine (d4T): 活化成ddTTP/阻止延長、衍生物Thymine(T)副作用: 周邊神經炎、乳酸中毒5.)Lamivudine (3TC): 抑制HIV/B肝反轉錄酶、衍生物(2-deoxy-3-thiacytidine/有硫)合併: +Zidovudine (AZT)6.)Abacavit: 抑制反轉錄酶、衍生物(G)副作用: SJS (HLA-B5701)7.)Tenofovir惠立妥: 抑制polymerase(NRTI)、懷孕B級副作用: 骨折、腎毒、腎差要調整8.)Emtricitavine (FTC): Lamivudine (3TC)氟化物
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