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AML pathogenesis:- Primarily affects older adults; median age is 50 years- Tumor of _____ _____ cells (acquired oncogenic/epigenetic mutations) --> Impede _____ --> Accumulation of immature myeloid blasts in the marrow- Replacement of marrow with _____ --> Marrow _____ and complications related to anemia, thrombocytopenia, and neutropenia- _____ gene mutations + Activation of _____ signaling pathways --> Decreased myeloid differentiation, increased myeloid proliferation
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