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An individual with only 50% of the normal level of PFK-1 enzyme activity was found to be lacking one copy of the PFK-1 gene. After testing more than 100 people who were genetically related to the individual, it was found that a few also had only one PFK-1 gene. What is the simplest explanation for why no individuals were found who lacked both gene copies of PFK-1? (ch9)
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