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au XVIIème siècle-représente l'introduction de la CHIMIE dans la thérapeutique-Substance purgative interdite à la vente par les faculté de médecine au début du XVIIème siècle-Délivrée par certains apothicaires malgré cette interdiction: querelle de l'antimoine pendant plusieurs années au XVIIème siècle-l'antimoine sera finalement réintroduit comme purgatif par certains médecins-Représente le désir d'émancipation des apothicaires qui ne supportent plus la tutelle médicale mise en place au XIIème siècle*apothicaires plus riches*solutions plus efficaces
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