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- Augmentation du nombre de mitoses- Présence de cellules mitotiques dans la couche épineuse- Perte de polarité cellulaire- Couche basale anarchique- Modification de la taille des cellules- Kératinisation prématurée de certaines cellules (dyskératose)- Apparition de perles de kératine dans la couche épineuse- Perte de différenciation des différentes couches épithéliales- Diminution de l’adhérence intercellulaire- Papilles épithéliales arrondies en forme de « goutte d’eau »- Modification du rapport nucléo-cytoplasmique, avec augmentation de la taille des nucléoles- Hyperchromatisme nucléaire- Noyaux atypiques (dyskaryosis), avec tendance au gigantisme ou au polymorphisme et à des divisions nucléaires sans division cytoplasmiqueTout ceci montre qu’il y a quelque chose qui se passe au niveau de cet épithélium.
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