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> Effets sur la croissance : les cell cancéreuses sont immortelles, leur division est indépdt des Facteurs de croissance et extrement rapide (envahissent le tissu dans lql elles se trouvent)> Modifications fctnl : -augmentation du métabolisme (besoin énergétiques importants car se dvlpt très rapidement)-production de Facteurs angiogéniques-augmentation de la sécrétion des protéases qui digèrent les élement protéiques de la MEC> Modifications morphologiques :-chgt profil d'expression des gènes = dédifférenciation qui les rapprochent des cell embryonnaires-expression de prot spcfq de tumeurs (marqueurs tumoraux)-perte d'adhrc (intercell et à la MEC) => mobilité accrue pour s'échapper du foyer primitif pour former des métastases
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