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En cas de baisse de la pression sanguine rénale, de baisse de la concentration en Na Cl au niveau de la macula densa ou d'hypovolémie il y a sécrétion de rénine par les cellules juxtaglomérulaire.La rénine permet alors l'obtention d'angiotensine à partir de l'angiotensinogène produit dans le foie. L'angiotensine permet alors une sécrétion d'ADH et d'aldostérone entraînant une rétention sodée dans le rein.
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