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→ entrée par endocytose (virion nu ou enveloppé) ou fusion (virion enveloppé)→ détournement des mécanismes cellulaires pour l'entrée du virus (l'endocytose est un mécanisme utilisé par la cellule pour récupérer les nutriments, recycler les récepteurs,... mais le virus l'utilise pour son propre fin qui est entré dans la cellule)
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