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- Established DEA- Regulated controlled substances- Control substances are highly addictive and habit forming- Group into 5 schedules (CI-CV)a. The Pure Food and Drug Act 1906b. The Food, Drug, and Cosmetic Art 1938c. The Durham - Humphrey Amendment 1951d. The Kefauver - Harris Amendment 1962e. The Controlled Substances Act 1970f. The Orphan Drug Act 1983
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