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Flumazenil (ROMAZICON). It is used clinically to counteract the sedative effect of benzodiazepine. They occupy benzodiazepine binding site on GABAAreceptor but have no effect on the chloride flux. Thus, the effects of benzodiazepine agonists can be reversed or prevented by the antagonist flumazenil, which competes with agonists for binding to the same site at GABAA receptor.
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