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GRAVES DISEASES management ATD therapycarbimazole is started at 40mg and reduced gradually to maintain euthyroidismtypically continued for 12-18 monthsthe major complication of carbimazole therapy is ====an alternative regime is termed 'block-and-replace' carbimazole is started at 40mg thyroxine is added when the patient is euthyroidtreatment typically lasts for 6-9 monthspatients following an ATD titration regime have been shown to suffer fewer side-effects than those on a block-and-replace regime

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