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HH pathophysiology:- Reduced _____ activity --> Abnormal iron-export by ferritin-iron in macrophage --> Tissue iron accumulation and damge- _____ _____ by iron-catalyzed free radical reactions- Interaction of _____ and iron radicals with _____ causing lethal cell injury and predisposition to hepatocellular carcinoma- Stimulation of _____ formation by activation of hepatic _____ cells- Clinical consequences: _____ and _____ developing in patients with a significant hepatic iron concentration of greater than 3x the normal level
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