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HL characteristic features:- Distinctive group of neoplasms that are characterized by the presence of a tumor giant cell, the _____-_____ (RS) cells- Occur at a single node or chain of nodes and spreads first to anatomically _____ lymphoid tissues (nontender _____ _____ lymphadenopathy)- Neoplastic Reed-Sternberg cells are derived from _____ cells --> Release factors that induce the accumulation of reactive lymphocytes, macrophages, and granulocytes (90% tumor cellularity)
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