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Il s'agit de la trétinoïne = acide 13-trans rétinoïque :- 1ère génération de rétinoïdes de synthèse.=> RSA : - Doubles liaisons formant un système conjugué - Fonction acide (existante ou induite par le métabolisme) - Cycle aromatique/système polycycliques augmentant le lipophilie.=> Inconvénients majeur : - Instable à la lumière. - Instable à l'oxygène.
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