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- In response to infection with M.tuberculosis, M/ph secrete IL-12 and TNF-α- These cytokines increase localized inflammation with the recruitment of T cells and NK cells into the area of the infected M/ph- Inducing T cell differentiation into Th1 cells with subsequent secretion of IFN-γ- In the presence of IFN-γ, the infected M/ph are activated, leading to increased phagosome-lysosome fusion and i/c killing

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