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Insulin signaling in liver cells leads to the phosphorylation (1) / dephosphorylation (2) of PFK-2/FBPase-2, which activates the PFK-2 activity of the enzyme and phosphorylation of fructose-6P (3) / fructose-1P (4). The net result of increased F-2,6-BP levels in liver cells is to stimulate (5) / inhibit (6) flux through the glycolytic pathway by allosterically-activating the enzyme aldolase (7) / phosphofructokinase-1 (8). In contrast, glucagon inhibits (9) / stimulates (10) protein kinase A (PKA) signaling in liver cells leading to the activation of the FBPase-2 domain of the dual function enzyme PFK-2/FBPase-2 which results in increased (11) / decreased (12) levels of F-2,6-BP.
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