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John and Jane are planning a family, but each has a brother who has sickle-cell disease, so they are concerned that their children may develop sickle-cell disease. Neither John, Jane, nor their respective parents have the disease. They consult a genetic counselor, who tells them that __________. A) all of their children will have sickle-cell disease B) it's possible that none of their children will have the disease, but tests on both of them will be required to make sure C) one of four of their children can be expected to have sickle-cell disease D) there is no chance that any of their children will have sickle-cell disease E) it is impossible to tell whether their children will have the disease
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