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La cavité buccale est tapissée par la muqueuse buccale, c'est à dire par un épithélium pavimenteux stratifié de type malpighien. Selon sa localisation, cet épithélium présente, des épaisseurs ainsi que des degrés variables de kératinisation en relation avec les frottements. Cet épithélium est maintenu humide par la sécrétion des glandes salivaires principales et accessoires. L'épithélium adhère fortement au derme ou chorion grâce à l'existence de papilles. Ces dernières sont plus développées là où les pressions exercées sur la muqueuse risquent d'induire un décollement épithélial.
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