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Michaelis and Menten assumed that the overall reaction for an enzyme-catalyzed reaction could be written as k1 k2E + S ES → E + P k-1Using this reaction, the rate of breakdown of the enzyme-substrate complex can be described by the expression: A) k1 ([Et] − [ES]). B) k1 ([Et] − [ES])[S]. C) k2 [ES]. D) k-1 [ES] + k2 [ES]. E) k-1 [ES].

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