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Name: Intranasal corticosteroids: fluticasone (Flonase), mometasone (Nasonex) (Giant nose, 'NAS' on nose)MOA: agonize the glucocorticoid receptor in nasal epithelium to reduce inflammation (G C in nares)Clinical: the recommended first-line treatment for moderate to severe persistent allergic rhinitis. The most effective treatment of allergic rhinitis available. (Mod to Severe, 1st)ADME: Begins working within hours, though maximal effect may take several days. Therapy is typically started at maximal dose until symptoms are controlled, then stepped down. Patients with severe symptoms will require daily chronic use.Though different formulations are similar in efficacy they vary in taste/odor and some may be more tolerable than others to patients (Hours to Days on bottom, Max with arrows down)AE: minimal due to topical application (Spray into nose, inhibit AE)

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