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Osteoblas familjen härstammar från mesenchymala stamceller. Under osteogenesen blir vissa (ca. 20%) osteoblaster kvar i benet som osteocyter inuti lacunae (vilka är metabolt inaktiva celler). När osteogenesen är avslutad minskar den metaboliska aktiviteten och cellerna blir platta liningceller på benytan. Dessa celler är post-mitotiska.
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