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- Outer membrane: LPS of AG- The source of infection - rodents (urine) and transmission trough water- Variable febrile onset (flu like symptoms), leptospiraemia (week 1) → liver, kidneys (week 2-3) (producing hemorrhage and necrosis of tissue, resulting in dysfunction of those organs, The IgM rises!!! → aseptic meningitis, nephritis, hepatitisIgM - 1 week - months after infectionIgG - 1 months- years
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