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Plus le taux d'Apaf-1 est élevé, plus le % de mort cellulaire est élevé après traitement par l'ADR. Les cellules avec une faible expression d'Apaf-1 ont un très faible taux de mort cellulaire et sont donc très résistantes au traitement par ADR. Cela suggère que l'absence d'apoptose dans les clones traités par l'ADR est due à une absence d'expression d'Apaf 1
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