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Prostate adenocarcinoma clinical course:- Localized --> Asymptomatic, usually discovered by the detection of a suspicious mole on rectal examination or _____ _____ _____ level- Most prostatic cancers arise peripherally away from the urethra, and therefore urinary symptoms occur late- Advanced tumor --> _____ symptoms, difficulty in starting or stopping the stream, dysuria, frequency, or hematuria

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