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- Show product effectiveness and safety are required- Report adverse events to FDA drugs- It began drug improval processa. The Pure Food and Drug Act 1906b. The Food, Drug, and Cosmetic Art 1938c. The Durham - Humphrey Amendment 1951d. The Kefauver - Harris Amendment 1962e. The Controlled Substances Act 1970f. The Orphan Drug Act 1983
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