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Strains of E. coli that are defective in mismatch repair have very high _level:s of spontaneous mutagenesis. Studies have shown that in wild-type strains A:C and G:T mispairings (as opposed to the normal A:T and G:C pairings) that occur during DNA replication are more likely than other mispairings (A:G, etc.) to be detected and repaired in these mismatch repair-proficient, wild-type strains. Which of the following types of base-pair substitutions would you expect to be most common among the spectrum of spontaneous mutations created by the mutant mismatch repair-defective strains?
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