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The most common mutation in patients with severe cystic fibrosis disease is a 3-nucleotide deletion in the CFTR gene. This mutation produces a CFTR protein that is missing one amino acid, phenylalanine at the 508th amino acid position (Phe508; aka F508). In normal CFTR protein, if Phe508 is not in a transmembrane domain, then this hydrophobic amino acid is most likely... (select all that apply) A.On the surface of the protein interacting with the aqueous environment B. On the exterior of the folded protein domain where it interacts with the polar head groups of the membrane lipids C. In the interior of the folded protein where it interacts with other hydrophobic amino acid side chains
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