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Treat both positive and negative signs of psychosis. They are considered serotonin-dopamine antagonists, as they maintain D2 antagonism but also have simultaneous serotonin 5HT2A antagonism. Serotonin (5HT) can regulate DA release directly or indirectly, producing various effects on dopamine (DA) neurons. 5HT1A and 5HT2A receptors have opposite actions on dopamine release.Stimulation of 5HT1A receptors increases dopamine release (a DA accelerator). Once bound to 5HT1A receptors, 5HT causes inhibition of its release, which results in increased dopamine output.

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