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Typiskt för platta ben ex. skallben, maxilla och mandibula.Benbildningen startar från mesenchymal vävnad (mjukvävnad) utan närvaro av brosk.- Osteogena celler differentieras lokalt.- ses som matrix-kondenseringar i mesenchymal vävnad.- Ett ossifikation center bildas.- En grupp mesenchymala celler differentieras till osteoblaster.- Dessa producerar osteoid-matrix som förkalkas vilket resulterar i inkapsling av vissa osteoblaster som då blir osteocyter.- Dessa öar av bildat ben formar väggar som avgränsar kaviteter som innehåller kapillärer, benmärgsceller och odifferentierade celler. Svampliknande utseende.- Ossifikation centres växer och smälter samman och ersätter bindväven.
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