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What is the biochemical basis for using primaquine as an antimalarial drug?Malarial parasites are acetylated on key surface proteins by the catalytic activity of the primaquine enzyme.Malarial parasites do not fully develop in the high ROS cellular environment induced by primaquine treatment.Malarial parasites are unable to metabolize primaquine as a food source and die from lack of oxygen.Primaquine is metabolized by liver enzymes to produce hydrochloric acid, which kills malarial parasites but not liver cells.Primaquine induces the production of ADP, which competes with ATP as an energy source for the parasite
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