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Why is the lagging strand synthesized in a discontinuous fashion? The DNA polymerase enzyme that synthesizes the lagging strand can only synthesize short sequences of DNA before it falls off the template. DNA synthesis must occur in a 5' to 3' direction, which imposes spatial constraints on the synthesis of the lagging strand. The lagging strand is complementary to the leading strand. All of these are reasons why the lagging strand is synthesized in a discontinuous fashion. The template of the lagging strand is discontinuous.
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