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基本的な生物学とライフサイクル- ダニに噛まれることで、細菌は皮膚を通過します。- 細菌の細胞表面には、上皮細胞に付着して侵入するためのアドヘシンタンパク質があります。- Yops(Yersinia outer proteins)と呼ばれる一群のタンパク質を放出します。- いくつかはマクロファージ、好中球、および他の貪食細胞に入り、貪食作用を崩壊させます。- その結果、Yersiniaは破壊される代わりにリンパ節に運ばれます。ここで、それはほぼ無制限に複製することができ、腫瘍(buboes)を作り出します。- もし患者が幸運ならば、感染はリンパ節に制限されたままであり、腫瘍が破裂し、患者は生存する可能性があります。- しかし、感染が血液に侵入すると、全身になる可能性があります。-
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