- Insoluble salts of a penicillin are used in what formulations?
- Which PBP of staphylococci is sensitive to methicillin?
- An electron withdrawing group in a cephalosporin (where the leaving group might be) increases what kind of activity?
- What type of adverse effect/side effect is described by: - cell mediated hypersensitivity that is mediated by T lymphocytes
- What specific type of beta - lactamase uses metals to open up the beta - lactam ring?
- What type of adverse effect/side effect is described by: - immune complexes, serum sickness - like reactions and drug fever
- Are ethers considered EWG or EDG?
- What is the primary indication for the use of the fifth generation cephalosporin?
- What specific type of beta - lactamases go after 3rd generation cephalosporins and carbapenems?
- What is the only 5th generation cephalosporin that is on the market for clinical use?
- What kind of coverage does ceftolozane have when given as a combination drug with tazobactam?
- What are the two most common irreversible beta - lactamase inhibitors?
- What is the renal function cutoff that we should start thinking about making dosing modifications?
- Most beta - lactams are also actively secreted into ___________ by a saturable system
- What substitution does 3rd generation cephalosporins have that make them unique?
- Distribution: - ____________ distribution to most areas of the body but __________ penetrates mammalian cells- very high concentrations are found in __________ - penetration into the _________ is negligible unless inflammation is present because inflammation alters the _______ pump that removes beta - lactams from CSF - ________ protein binding - beta - lactams (do/do not) cross the placenta well
- Are halogens considered EWG or EDG?
- What medication can be given as an IM injection for meningitis?
- What kind of coverage does ceftazidime have when given as a combination drug with avibactam?
- Extra low affinity for ___________ by staphylococci produces methicillin resistance (MRSA)