- Hb abnormalities, mismatched blood, bacterial or parasytical infections (malaria)
- A common stem cell (pluripotent= can be any blood cell)
- Sickle cell disease carrier has Hgb
- The main stimulus for RBC production is
- Proteins that elicit immune response and identifies the cell
- Binds to albumin in plasma, and goes to the liver => Goes into Bile and gets secreted
- "Committment" occurs when the cell has receptors that bind to Hematopoietic Growth Factors
- 1) Hypoxia2) Low blood Osmolarity3) Low blood Viscosity
- 1) Nutrition deficiency (iron, B12, Folic acid - B9)2) Pernicious anemia (no intrinsic factor, no gastric secretion)3) Renal anemia (no EPO)4) Aplastic anemia (destruction of red marrow via drugs/radiation)
- 1) Hemorrhagic2) Low Hgb Synthesis (4 subcategories)3) Hemolytic anemia
- They die after 120 days, and should go to the Spleen.But can get stuck in vessels also
- Sickles red cells cause anemia because they have a decreased
- 4-6 million per mm^3 (as shown on a RBC count in a CBC)
- Each Hgb contains _ heme groups; meaning 1 Hgb can carry up to _ oxygens
- Hgb S is a result of minor changes in the molecular structure causing profound changes in
- % of whole blood volume that is composed of RBC's
- Because RBCs do not undergo mitotic division, they are replaced by
- Folic Acid Anemia is different from Vitamin B12 anemia by lack of
- Hypoxia is sensed by the kidneys, which the produces the hormone
- When all 4 heme groups are bonded with oxygen, it is said to be