- For albumin list:1. the normal concentration in plasma2. the type of drug that binds to it3. an example
- with most condition (renal failure, burns, trauma, etc) concentration of alpha acid glycoprotein willa. increaseb. decrease
- T/F most drugs are not fully absorbed
- Fentanyl (Sublimaze): Pregnancy Category
- what does kinetic homogeneity state about the relationship between plasma drug concentration and concentration at the receptor site?
- what are the 3 transport processes that drugs can be delivered/distributed?
- what are two examples of uptake transporters?
- higher Cmax = a. faster absorptionb. slower absorption
- what organs have the highest perfusion of blood flow (therefore higher distribution)?
- T/F orally disintegrating tablets bypass first pass metabolism
- polar drugs display _______ absorption?a. the bestb. the poorest
- which is better able to cross membranes?a. lipophilic drugsb. hydrophilic drugs
- In what time frame do peak concentration usually occur?
- what determines the half life of a drug:a. absorption b. elimination
- Higher the AUC, the _____a. higher the bioavailabilityb. lower the bioavailability
- what is one important determinant of intestinal permeability?
- what is the transit time of a drug in the small intestine vs the large intestine?
- what is the transit time of drug from the mouth to the anus?
- what is the molecular weight at which permeability begins to decrease greatly?
- identify whether the following medications increase of decrease transit time of gastric emptying:1. laxatives2. pain killers, opioids3. anticholinergics (benadryl)4. prokinetics (metaclopramide, erythromycin)5. glp-1 agonists (diabetes/weight loss meds)